Research progress on the treatment of femoral skull necrosis by extracellular vesicles from bone marrow mesenchymal stem cells
10.3969/j.issn.1006-5725.2025.23.001
- VernacularTitle:骨髓间充质干细胞来源细胞外囊泡治疗股骨头骨坏死的研究进展
- Author:
Aiqiang LI
1
;
Ning ZHAO
;
Xusheng ZHANG
;
Haiping LIU
Author Information
1. 甘肃省中医院关节骨一科(甘肃 兰州 730050)
- Publication Type:Journal Article
- Keywords:
femoral head necrosis;
bone marrow mesenchymal stem cells;
extracellular vesicles;
bone repair
- From:
The Journal of Practical Medicine
2025;41(23):3631-3637
- CountryChina
- Language:Chinese
-
Abstract:
Osteonecrosis of the femoral head(ONFH)is a disabling orthopedic disease,pathologically characterized by progressive collapse of the femoral head accompanied by destruction of the trabecular and articular cartilage structures,leading to hip joint pain and progressive functional impairment.Bone marrow mesenchymal stem cell-derived extracellular vesicles(BMSC-EVs)show great promise in tissue repair and regeneration,with low immunogenicity and tumorigenicity,and play roles in osteogenesis,angiogenesis,and immunomodulation.This review summarizes the therapeutic effects and underlying mechanisms of BMSC-EVs in ONFH,providing a theoretical basis for its treatment.
