The research progress of inflammatory reaction driving breast cancer metastasis
10.11904/j.issn.1002-3070.2024.05.009
- VernacularTitle:炎症反应驱动乳腺癌转移的研究进展
- Author:
Dong LIU
1
;
Taijuan ZHANG
1
;
Jifeng DANG
1
Author Information
1. 青岛大学附属青岛市海慈医院(青岛市中医医院)放射科(青岛 266033)
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Inflammatory response;
Metastasis
- From:
Practical Oncology Journal
2024;38(5):336-341
- CountryChina
- Language:Chinese
-
Abstract:
The biggest challenge of breast cancer treatment is metastasis and drug resistance.Breast cancer metastasis increa-ses mortality and decreases the life quality of patients.At present,the mechanism of breast cancer metastasis is not completely under-stood,and the multi-step process of metastasis,namely metastasis cascade,is determined by the internal characteristics of tumor cells and tumor microenvironment.Among the factors driving breast cancer metastasis,the role of inflammatory reaction has gradually attrac-ted attention.The inflammatory environment composed of immune cells,cytokines,chemokines,and growth factors has an important im-pact on the invasion and metastasis of cancer cells.By studying the interaction between inflammatory reaction,tumor cells and tumor microenvironment,it is expected to discover drug targets for the prevention and treatment of breast cancer metastasis.This article re-views the role of inflammation in the tumor microenvironment of breast cancer metastasis.
