Research progress of IFN-γ in the treatment of tumor immune checkpoint inhibitors
10.11904/j.issn.1002-3070.2024.05.008
- VernacularTitle:IFN-γ在肿瘤免疫检查点抑制剂治疗中的研究进展
- Author:
Jiaying HE
1
;
Jinli ZHU
1
;
Kaixuan JIA
1
;
Peiying YANG
1
Author Information
1. 天津中医药大学第一附属医院肿瘤科(天津 300380);国家中医针灸临床医学研究中心;天津市中医肿瘤研究所
- Publication Type:Journal Article
- Keywords:
IFN-γ;
Cancer;
Immune checkpoint inhibitors;
Therapeutic resistance
- From:
Practical Oncology Journal
2024;38(5):330-335
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitors(ICIs)mainly promote anti-tumor immunity by relieving tumor immune suppression.Interferon-γ(IFN-γ)plays an important role in increasing tumor antigen presentation,inducing immune cell infiltration,and directly inducing tumor cell apoptosis,becoming a key factor in improving the efficacy of immunotherapy.The abnormal signaling pathway of IFN-γ and its own effect on promoting tumor are the key mechanisms that trigger resistance to ICIs therapy.Immunotherapy,when combined with IFN-γ or IFN-γ inducers,can effectively restore the presentation ability of MHC-I,increase immune cell infiltration,and thus improve the efficacy of immunotherapy.In addition,domestic and foreign scholars have achieved certain therapeutic effects on clinical trials by normalizing the IFN-γ signaling pathway and combining ICIs with JAKi.This review mainly introduces the role of IFN-γ in the treatment of tumor ICIs,providing direction for potential treatment strategies to reverse ICIs resistance and further provi-ding theoretical basis for clinical application.
