Role of TRIM13 in endoplasmic reticulum quality control and its association with diseases
10.3969/j.issn.1671-7856.2025.04.016
- VernacularTitle:TRIM13在内质网质量控制中的作用及其与疾病的关系
- Author:
Shiying YANG
1
;
Yuying RONG
1
;
Yuehong DONG
1
;
Lina JIANG
1
Author Information
1. 河北北方学院医学检验学院免疫教研室,河北 张家口 075000;河北北方学院微循环研究所,河北 张家口 075000
- Publication Type:Journal Article
- Keywords:
tripartite motif 13;
endoplasmic reticulum quality control;
endoplasmic reticulum-associated degradation;
endoplasmic reticulum autophagy
- From:
Chinese Journal of Comparative Medicine
2025;35(4):159-168
- CountryChina
- Language:Chinese
-
Abstract:
The endoplasmic reticulum quality control(ERQC)system is a core mechanism for maintaining cellular homeostasis,which primarily mediates the degradation of misfolded proteins in the endoplasmic reticulum(ER)through the ER-associated degradation(ERAD)and ER autophagy(ER-phagy)pathways.Tripartite motif 13(TRIM13)is a protein located on the ER membrane,which plays a critical role in ERAD via its E3 ubiquitin ligase activity.TRIM13 also acts as a non-classical ER-phagy receptor to mediate the occurrence of ER-phagy.TRIM13 has recently received extensive attention in the field of ERQC.Here we review the structure and function of TRIM 13 and the mechanisms by which it contributes to ERQC,and summarize its abnormal expression and regulatory role in diseases,with the aim of providing new strategies for the treatment of related diseases.
