The expression of IL-23 in breast cancer tissues and its correlation with clinicopathological characteristics
10.11904/j.issn.1002-3070.2024.05.007
- VernacularTitle:IL-23在乳腺癌组织中的表达及其与患者临床病理特征的相关性
- Author:
Minye YANG
1
;
Tongcheng XIAN
;
Jingjian LIU
;
Jun BIE
;
Jie WANG
;
Yi LUO
Author Information
1. 川北医学院附属南充市中心医院乳甲血管外科(南充 637000)
- Publication Type:Journal Article
- Keywords:
Interleukin-23;
Estrogen receptor;
Progesterone receptor;
Breast cancer;
Lymph node metastasis
- From:
Practical Oncology Journal
2024;38(5):323-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the expression of IL-23(IL-23)in breast cancer and its cor-relation with clinicopathological characteristics.Methods The tumor tissues and adjacent tissues of 100 patients with breast cancer diagnosed in Nanchong Central Hospital from January 2020 to December 2020 were collected.Immunohistochemistry and Real-Time PCR were used to determine the expression of IL-23 protein and mRNA in the two groups of tissues.The expression of IL-23 protein and mRNA in breast cancer tissues and adjacent tissues were compared,and the relationship between IL-23 expression and the clini-copathological characteristics of breast cancer was analyzed.Results IL-23 protein was mainly expressed in the membrane and cyto-plasm of breast cancer cells.The expression of IL-23 protein and mRNA in breast cancer tissues were higher than those in adjacent tissues(P<0.001).The expression of IL-23 protein and mRNA was positively correlated with the histological grade,T grade,clinical stage and Ki-67 expression of breast cancer,negatively correlated with the expression of ER and PR(P<0.05),and was not related to neurovascular invasion,age and HER-2 expression in breast cancer(P>0.05).Conclusion IL-23 may participate in the progres-sion of breast cancer,and its expression is closely related to ER,PR,Ki-67 and other prognostic indicators,suggesting that its expres-sion may be related to the prognosis,but it needs further experimental verification.
