Progress in murine models of pulmonary vascular plexiform lesions of pulmonary arterial hypertension
10.3969/j.issn.1671-7856.2025.04.013
- VernacularTitle:基于肺动脉高压的肺血管丛状病变的鼠类模型的研究进展
- Author:
Xinyu LI
1
;
Zhouxin REN
;
Peng ZHAO
Author Information
1. 河南中医药大学中医药科学院,郑州 450046
- Publication Type:Journal Article
- Keywords:
mouse;
rat;
pulmonary vascular plexiform disease;
multifactor stimulation model;
genetic engineering technology model
- From:
Chinese Journal of Comparative Medicine
2025;35(4):135-149
- CountryChina
- Language:Chinese
-
Abstract:
The need for suitable interventions for progressive pulmonary vascular lesions has become a bottleneck and a consequent focus in the prevention and treatment of clinical pulmonary hypertension.Plexiform lesions in pulmonary arterioles are the typical pathological manifestation of irreversible abnormal pulmonary vascular remodeling and the criterion for stage Ⅳ pulmonary vascular remodeling.There is currently no effective clinical intervention for such pathophysiological lesions,highlighting the need for corresponding animal models.This review considers new progress in the stereology of plexiform lesions and highlights plexiform-lesion models in mice and rats induced by multifactor stimulation,such as two-hit models and genetic engineering.It also evaluates the characteristics and applications of these models to provide a reference for animal experimental studies and to clarify the mechanism of pulmonary hypertension with pulmonary vascular plexiform lesions.
