Correlation study of methylenetetrahydrofolate reductase gene polymorphism and serum homocysteine levels with spontaneous abortion in early pregnancy in patients with polycystic ovary syndrome
10.3760/cma.j.cn115455-20240826-00738
- VernacularTitle:多囊卵巢综合征患者亚甲基四氢叶酸还原酶基因多态和血清同型半胱氨酸水平与妊娠早期自然流产的相关性研究
- Author:
Yunxia SONG
1
;
Lin SUN
;
Jing CUI
Author Information
1. 中国人民解放军联勤保障部队第九六七医院妇产科，大连 116000
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Pregnancy trimester, first;
Abortion, spontaneous;
Homocysteine;
5, 10-methylenetetrahydrofolate reductase
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(5):460-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of polymorphic typing of methylenetetrahydrofolate reductase (MTHFR) and serum levels of homocysteine (Hcy) on spontaneous abortion in early pregnancy in patients with polycystic ovary syndrome (PCOS).Methods:PCOS women, treated in Dalian Women and Children′s Medical Center (Group) from January 2022 to January 2024 were included in the study. One hundred patients with previous spontaneous abortion in early pregnancy were selected as the observation group (abortion group), and 72 patients with one successful pregnancy were delivered as the control group. The difference between gene polymorphism and serum Hcy levels at the C677T locus of MTHFR gene between the two groups, and serum Hcy level with the occurrence of spontaneous abortion in PCOS patients.Results:The serum Hcy level was higher in the PCOS abortion group than in the control group: 14.70 (12.20, 18.75) μmol/L vs. 9.60 (7.62, 10.80) μmol/L, with a statistically significant difference ( P<0.05). Between the abortion and control groups, genotype CC: 23.00% (23/100) vs. 44.44% (32/72), CT: 49.00% (49/100) vs. 31.94% (23/72), TT: 28% (28/100) vs. 23.61% (17/72) ( χ2 = 9.24, P = 0.010). Genotype CT, genotype TT and allele T were all risk factors for spontaneous abortion in early pregnancy in PCOS patients. The Hcy level of each genotype in the abortion group was significantly higher than that of the control group, all statistically significant ( P<0.05), and alleles C and T had similar results ( P<0.01). There was a trend towards gradually increasing Hcy levels for the three genotypes in the same group (CC
