Application of targeted degradomics in target identification of natural products
- VernacularTitle:靶向降解组学在天然产物靶标鉴定中的应用
- Author:
Yue-ying YANG
1
;
Zhi-qi ZHANG
;
Yang LIU
;
Jing LIANG
;
Hua LI
;
Wen XU
;
Li-xia CHEN
Author Information
- Publication Type:Journal Article
- Keywords: target degradomics(TGDO); natural products; PROTAC; differential quantitative proteomics; molecular probe; target identification
- From: Chinese Pharmacological Bulletin 2025;41(6):1040-1046
- CountryChina
- Language:Chinese
- Abstract: Natural products are an important source for innovative drugs,but unclear molecular targets and mechanisms limit their further development and application.The authors proposed a new method for the target identification of natural products based on proteolysis-targeting chimera(PROTAC)technology and quantitative proteomics,and established the targeted degradomics(TGDO) technology for the identification of weak-affinity tar-gets.This article summarizes the standardized workflow and the application of TGDO for target identification of natural products.
