Drug eruption induced by metformin
10.3760/cma.j.cn114015-20201025-01082
- VernacularTitle:二甲双胍致药物性皮炎
- Author:
Shan SHEN
1
;
Na JIANG
;
Weizhe LI
;
Wen ZHANG
;
Cuicui LU
Author Information
1. 山东第一医科大学附属省立医院药学部，济南 250021
- Publication Type:Journal Article
- Keywords:
Metformin;
Dermatitis;
Anaphylaxis
- From:
Adverse Drug Reactions Journal
2021;23(5):277-278
- CountryChina
- Language:Chinese
-
Abstract:
A 64-year-old male patient with type 2 diabetes mellitus received metformin 0.5 g thrice daily, acarbose 100 mg thrice daily, and saxagliptin 5 mg once daily orally. The patient developed itching and erythema symptoms during the treatments. The patient learned that metformin could cause adverse reactions such as pruritus and rash by reading the drug label. Then the metformin was stopped by himself and his skin symptoms were relieved within a few days. Due to elevated blood glucose, the patient took metformin again and developed erythema and papules 2 days later, but he didn′t stop the drug. After that, swelling of both lower limbs, accompanied by skin erosion and exudation appeared gradually. Laboratory tests showed that eosinophil count was 0.66×10 9/L. Drug eruptions caused by metformin was considered. All oral hypoglycemic drugs were stopped and symptomatic treatments such as antihistamine and glucocorticoid were given. Five days later, his erythema and papules gradually subsided, and erosive surface of both lower limbs crusted without exudation. Laboratory tests showed eosinophil count 0.06×10 9/L. Dermatitis did not recur after the patient switched to insulin to control blood glucose.
