Thrombocytopenia induced by cefathiamidine
10.3760/cma.j.cn114015-20201125-01176
- VernacularTitle:头孢硫脒致血小板减少
- Author:
Yan XU
1
;
Yan LI
1
;
Qiuhong YANG
1
Author Information
1. 济南市妇幼保健院妇产科，济南 250001
- Publication Type:Journal Article
- Keywords:
Cephalosporins;
Thrombocytopenia;
Antibiotic prophylaxis
- From:
Adverse Drug Reactions Journal
2021;23(5):275-276
- CountryChina
- Language:Chinese
-
Abstract:
A 31-year-old pregnant woman received an IV infusion of cefathiamidine 2 g dissolved in 0.9% sodium chloride injection 100 ml twice daily for prevention of infection during the perioperative period of cesarean section. Her platelet count (PLT) before medication was 166×10 9/L. Routine blood cell tests after the 2nd medication (21 h after operation) showed PLT 40×10 9/L. At 30 hours after the operation, the PLT decreased to the lowest level (14×10 9/L) and no bleeding symptoms occurred. Cefathiamidine was stopped, symptomatic and supportive treatments such as platelet supplement and intravenous infusions of immunoglobulin and methylprednisolone sodium succinate for injection were given. Four days later, her PLT returned to normal. The patient was followed up for 3 months postnatally, and the platelet level was normal.
