Comparison of accuracy of statistical parametric mapping at different confidence levels of 18F-fluorodeoxyglucose PET in locating temporal lobe epilepsy
10.3969/j.issn.1002-1671.2025.05.005
- VernacularTitle:统计参数图不同置信水平18F-氟代脱氧葡萄糖PET定位颞叶癫痫准确率比较
- Author:
Linghan WANG
1
;
Chunlei ZHAO
;
Hui LI
;
Xiaoyang WANG
;
Shangwen XU
Author Information
1. 福建医科大学福总临床医学院,福建 福州 350025
- Publication Type:Journal Article
- Keywords:
temporal lobe epilepsy;
epileptogenic focus;
confi-dence level;
statistical parametric mapping;
18F-fluorodeoxyglu-cose;
positron emission tomography
- From:
Journal of Practical Radiology
2025;41(5):742-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the accuracy of18F-fluorodeoxyglucose(18F-FDG)PET in locating the epileptogenic focus in patients with temporal lobe epilepsy using the single-patient research method based on statistical parametric mapping(SPM)at dif-ferent confidence levels,and to compare it with the asymmetry index(AI)analysis method.Methods A retrospective analysis was conducted on the clinical and imaging data of 86 patients with drug-resistant temporal lobe epilepsy and 37 healthy controls.The pri-mary epileptogenic focus were located by 18F-FDG PET,and two-sample t-test and intracranial asymmetry analysis were performed on individual patients based on SPM.The accuracy of 18F-FDG PET in locating the epileptogenic focus was compared at different confidence levels P＜0.05,P＜0.05[familywise error rate(FWE)corrected],P＜0.01,P＜0.001,respectively.The diagnostic accuracy of the SPM method at the optimal confidence level P value was compared with the AI analysis method,and the data were analyzed using the x2 test.Results The diagnostic accuracy of the two-sample t-test method were 69.77％,79.07％,67.44％ and 63.95％ at confidence levels of P＜0.05,P＜0.05(FWE corrected),P＜0.01 and P＜0.001,respectively;the diagnostic accuracy of the intracranial asymmetry analysis method were 94.19％,81.39％,79.07％,and 75.58％,respectively.There was a statistically significant differ-ence in diagnostic accuracy between the intracranial asymmetry analysis method(P＜0.05)and the two-sample t-test method P＜0.05(FWE corrected)(x2=8.482,P＜0.05);there was also a statistically significant difference in AI analysis method between the two methods(x2=4.793,P＜0.05).Conclusion The intracranial asymmetry analysis method(P＜0.05)based on SPM has a higher accuracy in locating the primary epileptogenic focus in unilateral drug-resistant temporal lobe epilepsy than those in the two-sample t-test method P＜0.05(FWE corrected)and AI analysis method.
