The risk factors for voriconazole-induced adverse reactions in patients with acquired immunodeficiency syndrome complicated with fungal infection
10.16718/j.1009-7708.2025.03.003
- VernacularTitle:艾滋病合并真菌感染患者使用伏立康唑致不良反应的危险因素分析
- Author:
Lili WU
1
;
Qiaoxi LI
1
;
Yan WANG
1
Author Information
1. 佛山市第一人民医院药学部,广东佛山 528000
- Publication Type:Journal Article
- Keywords:
voriconazole;
acquired immunodeficiency syndrome;
fungal infection;
adverse reaction;
risk factor
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(3):254-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors for voriconazole-induced adverse reactions in patients with acquired immunodeficiency syndrome(AIDS)for screening the high-risk populations and safe use of voriconazole.Methods Retrospective analysis was performed on patients who received voriconazole from January 2020 to December 2023.Demographic details,medical history,laboratory tests,concomitant medications,and adverse reactions of patients were collected from the hospital information system(HIS).The potential risk factors for the adverse reactions induced by voriconazole were analyzed by univariate and logistic multivariate analysis.Receiver operating characteristic(ROC)curve was used to analyze the specificity and sensitivity of the risk factors as predictor.Results A total of 170 patients were included in this study.Adverse drug reaction was reported in 62 patients(36.5％).Central nervous system toxicity,hepatotoxicity,and visual impairment were the most common adverse reactions.Univariate analysis showed that the adverse reactions of voriconazole were significantly associated with C-reactive protein,aspartic aminotransferase,aspartic aminotransferase/alanine aminotransferase,and CD4+T lymphocytes/CD8+T lymphocytes(CD4+/CD8+).Multivariate analysis indicated that CD4+/CD8+was an independent risk factor for voriconazole-induced adverse reactions.ROC curve indicated that CD4+/CD8+had a better predictive capability(AUC=0.756).Conclusions CD4+/CD8+should be monitored closely during voriconazole treatment for fungal infection in patients with AIDS.CD4+/CD8+may be a good predictor for voriconazole-related psychiatric and visual abnormalities and hepatotoxicity.
