MR quantification of the volume and iron deposition of gray matter nuclei in the deep brain of patients with type 2 diabetes mellitus and its association with cognitive impairment
10.3969/j.issn.1002-1671.2025.05.003
- VernacularTitle:2型糖尿病患者脑深部灰质核团体积和铁沉积与认知损害相关性的MR定量研究
- Author:
Bo YIN
1
;
Defeng DENG
;
Rui GUO
;
Ying WU
;
Na WAN
;
Jing MA
Author Information
1. 石河子大学医学院,新疆 石河子 832000;新疆生产建设兵团医院医学影像科,新疆 乌鲁木齐 830002
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
automatic brain segmentation technique;
brain iron deposition;
quantitative susceptibility mapping
- From:
Journal of Practical Radiology
2025;41(5):732-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of brain deep gray matter nucleus volume and iron content in patients with type 2 dia-betes mellitus(T2DM)based on quantitative MR technology,and their correlation and mediating effect with cognitive impairment.Methods A total of 60 T2DM patients(T2DM group)and 61 healthy controls(HC)(HC group)were prospectively selected.The volume of brain deep gray matter nucleus of 3D-T1 sequence map was measured by artificial intelligence(AI)automatic segmentation technique,the corresponding region of interest(ROI)was manually drawn and quantitative susceptibility mapping(QSM)value was measured on QSM,the cognitive score,QSM value and volume of nucleus were compared by independent sample t test and rank sum test,and the correlation analysis of imaging indexes with differences between the two groups was made.The mediating effect between fasting blood glucose(FBG)and Montreal cognitive assessment(MoCA)score was analyzed.Results The MoCA and mini-mental state examination(MMSE)scores in the T2DM group were lower than those in the HC group(P＜0.05),the volumes of bilateral caudate nucleus,putamen,globus pallidus,thalamus,and right hippocampus in the T2DM group were lower than those in the HC group(P＜0.05),and the QSM values of left caudate nucleus,thalamus and bilateral globus pallidus in the T2DM group were higher than those in the HC group(P＜0.05).In the T2DM group,the volumes of bilateral thalamus and right hippocampus were positively correlated with MoCA score(left thalamus:r=0.326,P=0.012;right thalamus:r=0.373,P=0.004;right hippocampus:r=0.509,P＜0.001),and the QSM value of left thalamus was negatively correlated with MoCA score(r=-0.263,P=0.044).The mediating effect of right hippocampus volume and left thalamus QSM value was significant(P＜0.05),and the direct effect of FBG on cog-nitive score was significant(P＜0.05).Conclusion Brain deep gray matter nucleus atrophy and brain iron deposition are closely related to T2DM and cognitive impairment,and there is a mediating effect.Brain iron deposition will increase the risk of cognitive impairment in T2DM.
