Death due to epidermolysis bullosa induced by topical application of blister beetle ( Mylabris) powder
10.3760/cma.j.cn114015-20190123-00081
- VernacularTitle:外用斑蝥粉中毒引起大疱性表皮松解症致死亡
- Author:
Yinyin LIU
1
;
Fan LI
1
;
Zhaopu FAN
1
;
Yalan HUO
1
Author Information
1. 新疆克拉玛依市中心医院皮肤科 834000
- Publication Type:Journal Article
- Keywords:
Cantharidin;
Psoriasis;
Administration, cutaneous;
Poisoning;
Epidermolysis bullosa
- From:
Adverse Drug Reactions Journal
2020;22(7):424-425
- CountryChina
- Language:Chinese
-
Abstract:
A 50-year-old male patient grinded his self-purchased blister beetle ( Mylabris) body into powder and then made it into paste for large area external use on his body skin for psoriasis. A few minutes later, the patient developed erythema and blisters on the site of medication; a few hours later, the purplish-red patches and blisters spread throughout the body, epidermis relaxed and exfoliated, and symptoms of systemic poisoning appeared. One day later, the patient developed multiple organ failure, such as respiratory failure, liver injury, kidney injury, severe hypoproteinemia, and abnormal coagulation function. Epidermolysis bullosa induced by externally application of Mylabris was diagnosed, and treatments of high-doses of pulsetherapy methylprednisolone, intravenous infusions of human immunoglobulin and human albumin, bedside hemofiltration, ventilator-assisted ventilation, and etc. were given. However, the patient′s condition deteriorated rapidly and finally he died of multiple organ failure 12 hours later.
