Glycosylated ceramide-related metabolic enzymes and atherosclerosis
- VernacularTitle:糖基化神经酰胺相关代谢酶与动脉粥样硬化
- Author:
Xin TAN
1
;
Qiang WEI
;
Yuan-hong LIAO
;
Jing-kun LU
Author Information
- Publication Type:Journal Article
- Keywords: glycosylceramide; atherosclerosis; glucosylceram-ide synthetase; glucocerebrosidase; lactosylceramide synthetase; galactosidas
- From: Chinese Pharmacological Bulletin 2025;41(6):1005-1010
- CountryChina
- Language:Chinese
- Abstract: Atherosclerosis is an arterial lesion involving abnor-mal lipid metabolism and an inflammatory response,and is the initiating factor of many cardiovascular and cerebrovascular dis-eases.Glycosylated ceramides are derivatives of ceramide mole-cules with a glycosylated group attached,which not only affect the structural integrity of cell membranes,but also regulate apop-tosis,inflammation and lipid metabolism,and disorders of glyco-sylated ceramide metabolism are closely related to the occurrence and progression of atherosclerosis.This review focuses on the specific functions of the glycosylated ceramide-related metabolic enzymes glucose ceramide synthetase,glucosylceramide syn-thetase,lactose ceramide synthetase,and galactosidase in athero-sclerosis,as well as their important effects on the development of atherosclerosis.Targeted therapeutic strategies for these meta-bolic enzymes,related drug development and significant potential in atherosclerosis prevention and treatment are also reviewed.
