Variable features of TFE3/TFEB translocation renal cell carcinoma:Impact of fu-sion partners and application of modern pathological diagnosis techniques
10.13315/j.cnki.cjcep.2025.05.001
- VernacularTitle:TFE3/TFEB易位性肾细胞癌的"多变特征":融合基因伴侣对病理特征的影响及现代病理学技术在准确诊断中的应用
- Author:
Xiaotong WANG
1
;
Qiuyuan XIA
1
;
Qiu RAO
1
Author Information
1. 解放军东部战区总医院/南京大学医学院附属金陵医院病理科,南京 210002
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
TFE3;
TFEB;
gene fusions;
histopathology;
molecular pathology
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(5):561-564,570
- CountryChina
- Language:Chinese
-
Abstract:
TFE3/TFEB translocation renal cell carcinoma(TFE3/TFEB tRCC)occupies a prominent position in the molecular pathological classification of renal cancers due to its distinctive genetic abnormalities and its clinical pre-dilection for younger patients.Over nearly two decades of research,the spectrum of TFE3/TFEB fusion partner genes has expanded,highlighting the increasing morphological heterogeneity of TFE3/TFEB tRCC.This article reviews the clinicopathological and molecular features of TFE3/TFEB tRCC,emphasizing the associations between the major fusion subtypes and their morphological manifestations as well as immunophenotypes.Additionally,the practical value of an-cillary diagnostic techniques,such as molecular testing,is summarized,aiming to provide a reference for the routine and differential diagnosis of TFE3/TFEB tRCC.
