The modulation of excitability in the anterior piriform cortex by locus coeruleus noradrenergic neuron
10.16557/j.cnki.1000-7547.2025.03.003
- VernacularTitle:蓝斑去甲肾上腺素能神经元对前梨状皮质兴奋性的调控
- Author:
Chi GENG
1
;
Xiaojie WANG
;
Xiao CHEN
Author Information
1. 徐州医科大学生物化学与分子生物学研究中心,徐州 221000
- Publication Type:Journal Article
- Keywords:
locus coeruleus(LC);
noradrenergic neurons;
anterior piriform cortex(aPC);
optogenetics odor repre-sentation;
mouse
- From:
Chinese Journal of Neuroanatomy
2025;41(3):281-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Locus coeruleus(LC)noradrenergic(NEergic)neurons densely project to anterior piriform cortex(aPC).However,the modulation of LC to aPC remains unclear.Therefore,this study aims to investigate the effect of LC-aPC projection on the modulation of aPC in odor perception.Methods:The AAV-DIO-ChR2-eYFP virus was injected into LC of DBH-Cre mice and the optrode was placed into aPC.Optogenetics combined with in vivo electro-physiology were used to record the air/odor-evoked response of aPC pyramidal neurons.Results:The immunofluores-cent staining showed that the LC project directly to aPC.Activation of aPC NEergic fibers decreased the spontaneous re-sponses and odor-evoked responses of aPC pyramidal neurons.Conclusion:Activation of aPC NEergic neurons inhibits the spontaneous responses and odor-evoked responses of aPC pyramidal neurons.
