Advances in natural product mechanism research based on target confirmation and single-cell multi-omics
10.12360/CPB202412094
- VernacularTitle:基于靶标确证与单细胞多组学的天然产物机制研究进展
- Author:
Na-na CHEN
1
;
Hao-jie DU
;
Yang SUN
Author Information
1. 南京中医药大学药学院
- Publication Type:Journal Article
- Keywords:
natural products;
target identification;
target vali-dation;
single-cell multi-omics;
small-molecule probe;
artificial intelligence(AI)
- From:
Chinese Pharmacological Bulletin
2025;41(6):1032-1040
- CountryChina
- Language:Chinese
-
Abstract:
Natural products are a treasure trove for new drug development,and more and more Natural products have shown great therapeutic potential in various diseases.Single-cell multi-omics technology,including single-cell genomics,single-cell transcriptomics,single-cell proteomics,single-cell epigenomics,etc.,is a multifaceted method for comprehensive analysis and research of single cells,providing more complete and accurate single-cell data.This offers deeper insights into the study of nat-ural product targets.This paper summarizes the methods and e-merging technologies used to identify and validate natural prod-uct targets,and reviews the application of emerging technologies like single-cell multi-omics and artificial intelligence in natural product pharmacology research.By combining target identifica-tion with the latest single-cell multi-omics research techniques,we can better elucidate the mechanism of action of natural prod-ucts,accelerate the innovation of traditional Chinese medicine,and promote its industrialization and internationalization.
