Association of HER2 expression with clinicopathologic features and prognosis in 519 cases of urothelial carcinoma
10.13315/j.cnki.cjcep.2025.05.008
- VernacularTitle:519例尿路上皮癌中HER2的表达与临床病理特征及预后的关系
- Author:
Aoling HUANG
1
;
Ting XIE
;
Hongfeng ZHANG
;
Shuaijun CHEN
;
Zhengzhuo CHEN
;
Bin LUO
;
Feng GUAN
;
Hong-lin YAN
;
Jingping YUAN
Author Information
1. 武汉大学人民医院病理科,武汉 430060
- Publication Type:Journal Article
- Keywords:
urothelial carcinoma;
bladder carcinoma;
HER2;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(5):602-607,613
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the immunohistochemical HER2 expression in a large group of patients with urothelial carcinoma and to compare the results with the pathologic features and survival rate.Methods A total of 519 urothelial carcinoma specimens were collected from two centers.HER2 expression was measured by EnVision immuno-histochemistry.HER2 expression was compared with clinicopathological parameters,and further analyzed in relation to patient prognosis.Results The median age of the 519 patients was 66 years with a male to female ratio of 1.93∶1.Among them,160 cases were radical specimens,and 359 were transurethral resection specimens.The overall HER2 positivity rate was 61.7％(320/519),of which 148 cases(28.5％)were HER2 1+,238(45.9％)were HER2 2+,and 82(15.8％)were HER2 3+.In addition,51 cases(9.8％)were HER2-negative.HER2-positive ex-pression was associated with age,tumor location,histological grade,histological type,surgical approach,lymphovas-cular invasion,and neural invasion(all P＜0.05),but there was no significant correlation with gender,pT stage,muscular invasion,or lymph node metastasis.Univariate and multivariate logistic regression analysis showed that age≥ 66 years,higher tumor grade,and lymphovascular invasion were risk factors for positive HER2 expression,and high histological grade and lymphovascular invasion were independent risk factors affecting HER2 expression after controlling for confounders.Survival analysis showed no significant difference in recurrence-free survival between patients with HER2-positive and HER2-negative non-muscle-invasive urothelial carcinoma(P=0.274).Conclusion High histologic grade,tumor lymphovascular invasion,and neural invasion were associated with positive HER2 expression in patients with urothelial carcinoma,and higher histologic grade and lymphovascular invasion are important factors affect-ing HER2 expression.However,HER2-positive expression may not affect the prognosis of patients with non-muscle-invasive bladder urothelial carcinoma.
