Research progress on the role and mechanism of ferroptosis in renal cell carcinoma
10.13315/j.cnki.cjcep.2025.05.014
- VernacularTitle:铁死亡在肾细胞癌中作用及其机制的研究进展
- Author:
Jixin YUAN
1
;
Zhiming WANG
1
;
Zhifei CAO
1
;
Yongsheng ZHANG
1
Author Information
1. 苏州大学附属第二医院病理科,苏州 215004
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
ferroptosis;
GPX4;
lipid peroxides;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(5):639-643
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma(RCC)is the most common type of malignant kidney tumors,originating from re-nal tubular epithelial cells.The primary treatment options for RCC include surgery and targeted therapy.Despite the notable advancements in RCC research,significant challenges persist,including the high risk of metastasis and recur-rence post-surgery,as well as the low sensitivity to radiotherapy and chemotherapy.Ferroptosis,a form of regulated cell death first identified in 2012,has garnered significant attention due to its involvement in several cellular processes,including redox balance,iron metabolism,and various signaling pathways related to cancer progression.Given its po-tential to be modulated,ferroptosis offers significant promise for the treatment of cancers,ischemic organ damage,and other degenerative diseases associated with lipid peroxidation.This review discusses recent developments in ferroptosis research,with a particular focus on its role in RCC,and explores future research directions in this area.
