Correlation between MHR and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
10.11969/j.issn.1673-548X.2024.11.019
- VernacularTitle:MHR与2型糖尿病患者颈动脉粥样硬化病变的相关性分析
- Author:
Qingwei GAO
1
;
Chunli LU
1
Author Information
1. 441300 湖北医药学院附属随州医院内分泌科
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Carotid atherosclerosis;
Monocyte to high-density lipoprotein cholesterol ratio
- From:
Journal of Medical Research
2024;53(11):95-99,112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between monocyte to high-density lipoprotein cholesterol ratio(MHR)and ca-rotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 457 cases of T2DM admit-ted to the Department of endocrinology,Suizhou Hospital Affiliated to Hubei University of Medicine from June 2020 to June 2023 were ret-rospectively collected.According to the measured carotid intima-media thickness(CIMT),the patients were divided into three groups:normal CIMT group(n=104),CIMT thickening group(n=113)and CAS plaque group(n=240).The general data,biochemical in-dexes and MHR of each group were compared,and the correlation between MHR and other indexes in T2DM patients was analyzed.Logis-tic regression analysis was used to analyze the influencing factors of CAS plaque formation in T2DM patients.The receiver operating char-acteristic(ROC)curve was used to analyze the predictive value of MHR in CAS plaque formation in T2DM patients.Results The MHR of CAS plaque group was higher than that of CIMT normal group and CIMT thickening group(P＜0.05).Spearman correlation analysis showed that in patients with T2DM,MHR was positively correlated with body mass index(BMI),neutrophil(NEU),lymphocyte(LY),monocyte(MO),creatinine(Cr)and uric acid(UA),and negatively correlated with glycosylated hemoglobin A1c(HbA1c),total cho-lesterol(TC)and high density lipoprotein cholesterol(HDL-C)(P＜0.05).logistic regression analysis showed that MHR was a risk factor for CAS plaque formation in patients with T2DM.ROC curve analysis showed that the area under the curve(AUC)of MHR for pre-dicting CAS plaques in T2DM patients was 0.593(95％CI:0.541-0.645,P=0.001),and the optimal cut-off value was 0.34,the sensitivity and specificity for the diagnosis of CAS were 63.3％and 51.2％.Conclusion MHR is closely related to CAS lesions in pa-tients with T2DM,and has a certain predictive value for the formation of CAS plaques.
