Osteolipoma of thyroid gland:a clinicopathological study of 7 cases
10.13315/j.cnki.cjcep.2025.05.010
- VernacularTitle:甲状腺骨性脂肪瘤7例临床病理观察
- Author:
Long ZHANG
1
;
Wenqing HUANG
1
Author Information
1. 中山大学孙逸仙纪念医院病理科,广州 510120
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
lipoma;
ossification;
pathological features;
imaging
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(5):614-617,626
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathologic features and imaging characteristics of osteolipoma in thyroid gland,and to improve the understanding and diagnosis of the disease.Methods The clinical,pathological,and imaging data of 7 cases of osteolipoma in thyroid gland were retrospectively analyzed,and the histological morphol-ogy of thyroid osteolipoma was observed using hematoxylin-eosin(HE)staining,the pathological changes and imaging manifestations of the disease were analyzed,and relevant literature was reviewed.Results The study included 2 male and 5 female patients,with a male-to-female ratio of 1∶2.5.The patients were ranged in age from 30 to 77 years,with a mean age of 54.3 years.The clinical symptoms were mainly anterior cervical tumor.Laboratory examination showed normal thyroid function 5 cases(5/7),slightly decreased thyroid stimulating hormone(TSH)in 1 case(1/7),in-creased free triiodothyronine(FT3)and decreased TSH in 1 case(1/7).Preoperative ultrasound examination(7/7)showed solid nodules in the thyroid gland,with smooth edges,hypoechoic solid components,and coarse calcifications in the nodules;X-ray computed tomography(CT)examination(2/7)showed thyroid mixed density nodules with clear boundaries.Histological morphology showed that the tumor was composed of mature adipose tissue and bone tissue with different proportions,and the cells exhibited no atypia or necrosis,and mitotic figures were rare.Two cases were com-plicated with papillary thyroid carcinoma and 3 cases with nodular goiter.All cases received surgical treatment,and were followed up from 11 to 42 months,without tumor recurrence.Conclusion Osteolipoma of thyroid gland is rare in clinic and has relatively specific pathological characteristics and imaging changes,aiming to improve the understanding of the pathological and imaging manifestations of osteolipoma.
