Correlation Analysis of Marginal Zone Enhancement Features and Quantitative Parameters of Contrast-enhanced Ultrasound with Ki-67 in Invasive Breast Carcinoma of No Specific Type
10.11969/j.issn.1673-548X.2024.11.015
- VernacularTitle:非特殊型浸润性乳腺癌超声造影边缘带增强特征及定量参数与Ki-67的相关性分析
- Author:
Jingjie WANG
1
;
Chunmei JIA
1
;
Yaodong CHEN
1
Author Information
1. 030001 太原,山西医科大学第一医院超声科
- Publication Type:Journal Article
- Keywords:
Invasive breast carcinoma of no specific type;
Contrast-enhanced ultrasound;
Marginal zone;
Ki-67
- From:
Journal of Medical Research
2024;53(11):73-76,63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between marginal zone two-dimensional ultrasound features,enhancement fea-tures and quantitative parameters of contrast-enhanced ultrasound and Ki-67 in the invasive breast carcinoma of no specific type(IBC-NST).Methods From October 2019 to October 2023,84 patients with IBC-NST(84 unilateral lesions),aged 25 to 78 years,confirmed by surgical pathology and immunohistochemistry were collected from the First Hospital of Shanxi Medical University.All patients had not received preoperative chemoradiotherapy,and underwented two-dimensional ultrasound and contrast-enhanced ultrasound exam-ination.They were divided into high expression group and low expression group according to the expression degree of Ki-67.The two-dimensional ultrasound features and contrast-enhanced ultrasound features and quantitative parameters of two groups were analyzed and compared,and their correlation between the quantitative parameters and Ki-67 was analyzed.Results The proportion of margin indis-tinct of IBC-NST lesion in Ki-67 high expression group was higher than that in Ki-67 low expression group,and the differences were statistically significant(P＜0.05).The proportion of adial enhancemen and the range enlargement after angiography of IBC-NST lesion in Ki-67 high expression group was higher than those in Ki-67 low expression group,and the differences were statistically significance(P＜0.05).The quantitative parameters peak intensity(PI),area under the curve(AUC)of IBC-NST lesion in Ki-67 high expres-sion group were higher than those in Ki-67 low expression group,and the differences were statistically significant(P＜0.05).IBC-NST marginal zone quantitative parameters PI,AUC were positively correlated with Ki-67 expression,and the differences were statistical-ly significant(P＜0.05).Conclusion In patients with IBC-NST,the marginal zone of the lesion is margin indistinct,the radial en-hancement,the srange enlargement after angiography,and the quantitative parameters PI,AUC are increased,indicating the high expres-sion of Ki-67,providing certain imaging guidance for clinical individualized precision treatment.
