Exploring the Comorbidity Mechanisms of Diabetes Mellitus and Atherosclerosis from the Bioinformatics Perspective
10.11969/j.issn.1673-548X.2024.11.009
- VernacularTitle:基于生物信息学视角探索糖尿病与动脉粥样硬化的共病机制
- Author:
Qian XU
1
;
Wenting WANG
1
;
Yanfei LIU
1
Author Information
1. 100091 北京,中国中医科学院西苑医院、国家中医心血管病临床医学研究中心
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Atherosclerosis;
Differentially expressed genes;
Pathogenesis;
Bioinformatics analysis
- From:
Journal of Medical Research
2024;53(11):39-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the comorbidity mechanisms between diabetes mellitus(DM)and atherosclerosis(AS)from the perspective of bioinformatics.Methods By analyzing gene expression profiles of DM and AS from the GEO database,differentially expressed gene(DEG)were identified and subjected to enrichment analysis.The CytoScape software was utilized to construct a protein-protein interaction network of DEG and to select core genes.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis was performed to elucidate the biological functions of the core genes.Results A total of 77 overlapping DEG were i-dentified.Enrichment analysis showed that these DEG were mainly involved in multiple biological pathways including immune response,intracellular and extracellular structure,and regulation of immune-related activities.Fifteen core genes were selected,and GO and KEGG enrichment analysis revealed their critical roles in regulating immune responses,participating in inflammation signaling pathways,and regulating metabolic pathways.They were closely related to multiple pathways including phagosome,formation of neutrophil extracel-lular traps,Toll-like receptor signaling pathways,lipid and AS.Conclusion The common pathogenesis mechanisms of DM and AS pri-marily involve inflammation and immune responses.Core genes play a crucial role in regulating immune responses,participating in inflam-matory signal transduction,and modulating metabolic pathways.
