Research progress on the predictive value of inflammatory markers for early neurological deterioration after reperfusion in acute ischemic stroke

VernacularTitle:炎症指标对急性缺血性卒中静脉溶栓治疗预后预测价值的研究进展
Author: Zihao ZHU ¹ ; Zhihong ZHAO ¹
Author Information

1. 湖南省人民医院（湖南师范大学附属第一医院）神经内科，长沙　410005
Publication Type:Journal Article
Keywords: Ischemic stroke; Thrombolytic therapy; Inflammatory indicators; Prognosis
From: Journal of Chinese Physician 2025;27(10):1597-1600
CountryChina
Language:Chinese
Abstract: Acute ischemic stroke (AIS) is the main subtype of stroke, caused by impaired blood supply to the brain. Timely restoration of blood perfusion is crucial for improving prognosis. A growing number of studies have shown that inflammatory markers and blood biomarkers, such as C-reactive protein (CRP), lymphocyte-to-monocyte ratio (LMR), monocyte-to-high-density lipoprotein ratio (MHR), and systemic immune-inflammation index (SII), have predictive effects on the prognosis of intravenous thrombolysis (IVT) in ischemic stroke. This article summarizes the research progress of inflammatory markers related to the prognosis of IVT in AIS, aiming to early identify adverse prognosis (such as early neurological deterioration, END) in patients undergoing IVT, conduct risk stratification for patients, formulate precise and effective treatment plans, and reduce related complications.