The study on the characteristics of gut microbiota in Parkinson disease with depression and its correlation with self-regulation psychological factors
10.3969/j.issn.1002-0152.2025.05.003
- VernacularTitle:帕金森病伴抑郁患者肠道菌群特征及其与心理因素相关性研究
- Author:
Fu XIE
1
;
Gan TANG
1
;
Nan YANG
1
;
Jing CHEN
1
;
Tao ZOU
1
Author Information
1. 贵州医科大学附属医院精神科(贵阳 550004)
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Major depressive disorder;
Parkinson disease with depression;
Gut microbiota;
16S rRNA;
Psychological factor;
Pleasure experience;
Rumination;
Psychological resilience;
Self-compassion
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(5):274-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences in gut microbiota among patients with Parkinson disease(PD),major depressive disorder(MDD)and PD with depression(dPD),as well as their correlation with psychological factors.Methods A cross-sectional control design was used for the study.Fecal samples were collected from 30 PD patients,21 dPD patients,and 20 MDD patients for high-throughput 16S rRNA sequencing analysis.The Snaith-Hamilton pleasure scale(SHAPS),ruminative responses scale(RRS),Connor-Davidson resilience scale(CD-RISC)and self-compassion scale short form(SCS-SF)were used for psychological assessments.Results The relative abundance of Megamonas was higher in the MDD group than in the dPD and PD groups,while Prevotella was lower in the MDD group than in the dPD and PD groups.The relative abundance of Escherichia-Shigella in PD was higher than that in the dPD and MDD groups,and the difference was significant(P<0.05).The score of the CD-RISC was positively correlated with the abundance of microbiota at Vibrio(r=0.598,P<0.001)and Shewanella(r=0.569,P<0.001),while the score of ruminative responses scale was positively correlated with the abundance of microbiota at Hydrogenophaga(r=0.625,P<0.001),Rhodococcus(r=0.510,P<0.001).Conclusion There are some differences in gut microbiota among patients with Parkinson disease,Parkinson disease with depression and major depression disorder.The specific microbiota such as Vibrio and Rhodococcus may be related to the psychological factors and depressive symptoms of dPD patients.
