Correlation between brain imaging features and cognitive impairment in end-stage renal disease patients based on susceptibility-weighted imaging
10.3969/j.issn.1674-8115.2025.06.011
- VernacularTitle:基于磁敏感加权成像的终末期肾病患者脑影像特征与认知功能损伤的相关性
- Author:
Liangrui GU
1
;
Bicong YAN
1
;
Tonglei FANG
1
;
Jinliang WU
1
Author Information
1. 上海交通大学医学院附属第六人民医院放射科,上海 200233
- Publication Type:Journal Article
- Keywords:
end-stage renal disease(ESRD);
cerebral microbleed(CMB);
cognitive impairment;
susceptibility-weighted imaging(SWI)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(6):760-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective·To assess the number and distribution of cerebral microbleeds(CMBs)in patients with end-stage renal disease(ESRD)using susceptibility-weighted imaging(SWI),and to explore the relationship between SWI-detected imaging features and cognitive impairment.Methods·Hospitalized ESRD patients who had received dialysis treatment for more than one year at Shanghai Sixth People's Hospital,Shanghai Jiao Tong University School of Medicine,between January 2023 and March 2024 were included.All patients underwent conventional MRI sequences and SWI scanning.The number and regional distribution of CMBs were recorded.Cognitive function was assessed using the Montreal Cognitive Assessment(MoCA).Patients with MoCA scores≥26 were classified into the ESRD without cognitive impairment group,and those with scores<26 were placed in the ESRD with cognitive impairment group.The presence and number of CMBs were analyzed in relation to cognitive impairment.The distribution of CMBs in various brain regions was examined,and correlations between the number of CMBs in specific regions and the severity of cognitive impairment were evaluated.Results·A total of 38 patients were enrolled,including 16 in the ESRD with cognitive impairment group and 22 in the non-impaired group.CMBs were more frequently observed in the cognitively impaired group(14 cases,87.50%)compared to the non-impaired group(12 cases,54.55%),with a statistically significant difference(P=0.033).The impaired group had more CMBs(106 in total),primarily located in bilateral cortical and subcortical regions(59.43%)and the basal ganglia(19.81%).In contrast,the non-impaired group had fewer CMBs(47 in total),mainly located in the bilateral basal ganglia(46.80%)and cortical and subcortical regions(40.43%),with all regional distribution differences being statistically significant(both P<0.05).Among those with cognitive impairment,the number of CMBs in the cortical and subcortical areas was significantly negatively correlated with cognitive function(r=-0.718,P=0.030).Conclusion·The number and distribution of CMBs detected by SWI in ESRD patients are associated with both the presence and severity of cognitive impairment.SWI can be used to identify CMBs formation and localization in ESRD patients,thereby aiding in the assessment of cognitive dysfunction.
