Mechanism of ultrafine garlic powder in improving mouse atherosclerosis and dyslipidemia
10.12360/CPB202410070
- VernacularTitle:大蒜超细粉改善小鼠动脉粥样硬化及血脂异常的作用机制
- Author:
Ning-ning SHAO
1
;
Jian-ming YANG
;
Yao-guang WANG
;
Tao ZHANG
;
Xiao-ming ZHAO
;
Jin-rui DONG
Author Information
1. 天津大学医学院,天津 300072
- Publication Type:Journal Article
- Keywords:
ultrafine garlic powder;
atherosclerosis;
dyslipidemia;
inflammation;
fibrosis;
MAPK signaling pathway
- From:
Chinese Pharmacological Bulletin
2025;41(7):1376-1381
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the mechanism of ultra-fine garlic powder(UGP)in ameliorating dyslipidemia and aortic inflammation and fibrosis in atherosclerotic(AS)mice.Methods A 10-week ApoE-/-mouse AS model was constructed,cardiac index was meas-ured,and aortic histopathological changes were ob-served by oil red O staining.Serum inflammatory factor levels were detected by ELISA,and the expression of JNK,NF-κB,ERK and their phosphorylated proteins were detected by Western blot.Results Cardiac in-dex and other indicators as well as aortic lesions were worsened in the AS group,as compared with the normal control group.Compared with the AS group,the UGP treatment group and the traditional garlic grinding pow-der(TGP)treatment group significantly decreased total cholesterol(TC),triglyceride(TG),low-density lipo-protein cholesterol(LDL-C),atherosclerosis index(AI1,AI2),and coronary cardiac index and restored high-density lipoprotein cholesterol(HDL-C)levels,and the area of aortic lesions,inflammation and fibrosis were significantly improved,and at the same time,sig-nificantly inhibited the expression of TNF-α,IL-1β,and IL-6,as well as the expression of p-JNK,p-NF-κB and p-ERK proteins.The therapeutic effect of the UGP group was superior to that of the TGP group.Conclu-sion UGP can significantly inhibit the formation of aortic endothelial AS plaques,reduce the levels of in-flammation and fibrosis,and regulate blood lipids in a-orta of AS mice.
