Effect of edaravone on post-stroke depression in rats based on HO-1/GPX4 signaling pathway
10.12360/CPB202411068
- VernacularTitle:基于HO-1/GPX4信号通路探讨依达拉奉对脑卒中后抑郁大鼠的影响
- Author:
Miao-miao MO
1
;
You-qiong WANG
;
Si-min XIE
;
Si-ting FAN
;
Bin YANG
Author Information
1. 广西医科大学药学院,广西南宁 530022
- Publication Type:Journal Article
- Keywords:
edaravone;
post stroke depression;
oxida-tive stress;
inflammation;
HO-1;
GPX4
- From:
Chinese Pharmacological Bulletin
2025;41(7):1354-1359
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of edaravone(EDA)on depression-like behaviors in a rat model of post-stroke depression(PSD)and to explore the un-derlying mechanisms.Methods SD rats were ran-domly divided into:sham operation group(Sham),cerebral ischemia group(CI),post-stroke depression(PSD),fluoxetine(10 mg·kg-1)group,and EDA(5,15 mg·kg-1)group.A PSD rat model was estab-lished using the suture method combined with 56 d of chronic unpredictable mild stimulation.Drug treatment was given once daily for 28 d after stimulation.Body weight and sucrose water preference were measured during the stimulation period,and serum TNF-α,IL-1 β,IL-6,MDA,SOD levels,and hippocampal tissue HO-1 and GPX4 protein expression were detected at the end of stimulation.Results Compared with the sham group,the rat neurological function scores of the remaining groups increased(P＜0.01).Compared with the PSD group,EDA increased the body weight and sucrose water preference of the rats(P＜0.01),significantly decreased the serum TNF-α,IL-1β and IL-6 levels,decreased the MDA level,increased the SOD level(P＜0.01),and up-regulated hippocampal HO-1 and GPX4 protein expression(P＜0.01).Con-clusions EDA improves depression-like behaviors and inhibits peripheral inflammation and oxidative stress in-jury in PSD rats,and its mechanism may be related to the activation of HO-1/GPX4 pathway to inhibit oxida-tive stress.
