A study on factors influencing the duration of therapeutic effect of Botulinum Toxin Type A in the treatment of benign essential blepharospasm
10.3969/j.issn.1002-0152.2025.04.002
- VernacularTitle:A型肉毒毒素治疗良性特发性眼睑痉挛疗效持续时间的影响因素研究
- Author:
Junhao HU
1
;
Hao WANG
;
Qinying MU
;
Fuhao MA
;
Ming SHI
Author Information
1. 空军军医大学西京医院神经内科(西安 710032);中国人民解放军联勤保障部队第987医院神经内科
- Publication Type:Journal Article
- Keywords:
Benign essential blepharospasm;
Botulinum toxin type A;
Injection method;
Pretarsal;
Preseptal;
Duration of therapeutic effect;
Influencing factor
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(4):211-217
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study aimed to explore the factors influencing individual variations in the therapeutic efficacy of botulinum toxin type A(BoNT-A)in the treatment of benign essential blepharospasm(BEB).Methods A retrospectively analysis was performed on the general information of 40 BEB patients who received BoNT-A injections at our center between 2018 and 2023.The information included gender,age,education level,disease duration,number of injections,injection dose,severity of clinical symptoms,injection methods,and other relevant factors.All patients received both the pretarsal(PT)injection and the PT combining with preseptal(PS)injection(PT-PS).A multivariate linear regression analysis was used to statistically analyze the factors affecting the duration of therapeutic effect(DOT).Results Multiple regression analysis showed that gender,age,education level,clinical symptoms and injection method were closely related to the DOT[F(8,71)=4.372,P<0.001],with the injection method being the strongest predictor.Specifically,the mean DOT for the two injection methods was 136.00(123.00,156.50)days,with the PT-PS method significantly longer than the PT method[144.50(132.25,161.75)vs.125.00(114.00,145.25),P<0.001].Conclusion Gender,age,educational level,clinical symptoms,and injection method are predictive indicators for the DOT of BoNT-A in BEB patients.Specifically,DOT is positively correlated with age but negatively correlated with educational level and severity of clinical symptom.Additionally,the DOT is longer in male patients compared to female patients and in those treated with the PT-PS injection method compared to the PT injection method.
