Research progress on cognitive impairments and emotional disorders in patients with pituitary neuroendocrine tumors
10.3969/j.issn.1002-0152.2025.04.008
- VernacularTitle:垂体神经内分泌肿瘤患者并发认知障碍及情绪异常研究进展☆
- Author:
Jingyun YANG
1
;
Guanling XIE
1
;
Shun YAO
1
Author Information
1. 国家临床重点专科,中山大学附属第一医院神经外科(广州 510080)
- Publication Type:Journal Article
- Keywords:
Pituitary neuroendocrine tumors;
Psychiatric and psychological abnormalities;
Cognitive dysfunction;
Emotional dysregulation;
Quality of life
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(4):246-251
- CountryChina
- Language:Chinese
-
Abstract:
Pituitary neuroendocrine tumors(PitNETs)are benign tumors originating from the pituitary gland.Although surgical and pharmacological treatments can achieve gross total resection of the tumor and restore endocrine function,patients often experience cognitive dysfunction and emotional regulation disorders,which can reduce their quality of life.Different types of PitNETs present with varying psychological and mental symptoms.For example,patients with prolactinomas,growth hormone-secreting pituitary tumors,and adrenocorticotropic hormone-secreting pituitary tumors commonly experience cognitive impairment(e.g.,memory and executive function)and emotional dysregulation(e.g.,anxiety and depression).Patients with non-functioning PitNETs commonly experience headaches and visual disturbances due to the mass effect of the tumor.Additionally,some of these patients may also develop cognitive impairments.Future research should focus on elucidating the specific mechanisms by which PitNETs influence neuropsychological function,developing more precise bedside assessment tools,and exploring personalized intervention strategies to improve overall treatment outcomes and quality of life for these patients.
