Research hotspots and trends of functional cure of hepatitis B based on bibliometric analysis
10.3969/j.issn.1672-8467.2025.02.001
- VernacularTitle:基于文献计量的乙肝功能性治愈研究热点与趋势分析
- Author:
Qi-ran ZHANG
1
;
Bing CAO
;
Ji-bin XIN
;
Li-jun WU
;
Yu-lei SUN
;
Jun YING
;
Wen-hong ZHANG
Author Information
1. 复旦大学附属华山医院感染科 上海 200040;国家传染病医学中心 上海 200040
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
functional cure;
bibliometric analysis;
research hotspots;
trends
- From:
Fudan University Journal of Medical Sciences
2025;52(2):159-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the global literature related to functional cure of hepatitis B from 2019 to 2023 by using bibliometric analysis methods,so as to help researchers understand the research hotspots and trends in this field.Methods The literature related to the topic of functional cure of hepatitis B included in the Science Citation Index Expanded(SCI-Expanded)of the Web of Science Core Collection from 2019 to 2023 was searched.By using VOSviewer and CiteSpace visual analysis tools,analyses were conducted from the perspectives of publication trends,international research cooperation networks,and keyword emergence,and were elaborated with the specific contents of the related literature to elucidate research hotspots and trends.Results A total of 600 eligible papers in this field were included.Keyword co-occurrence and thematic clustering suggested that the main research directions of functional cure were:serum biomarkers for prediction and monitoring of functional cure,functional cure and immunity,nucleoside analog discontinuation,interferon therapy,and long-term prognosis of functional cure.The research contents of the ESI highly cited original research papers were similar to the clustering of the above,but showed more attention on the novel agents for functional cure.The content of the keyword emergence map showed that hotspots of interest changed from virologic mechanisms and serum markers,to nucleoside analog discontinuation and interferon therapy,and finally to immunologic mechanisms and new drug.Conclusion The research hotspots and trends of functional cure of hepatitis B were focused on virological mechanism,serum markers,immunological mechanism,nucleoside analog discontinuation,interferon therapy,and long-term prognosis after cure.
