Effect of Nogo-A/NgR pathway on prepulse inhibition reduction induced by psychedelics in mice
- VernacularTitle:Nogo-A/NgR通路对经典致幻剂降低小鼠前脉冲抑制反应的影响
- Author:
Ying QU
1
;
Yue-ying WANG
;
Yi SUN
;
Rui-bin SU
Author Information
- Publication Type:Journal Article
- Keywords: psychedelic; animal model; prepulse inhi-bition; Nogo-A protein; NgR receptor; Rtn4r gene knockout
- From: Chinese Pharmacological Bulletin 2025;41(7):1231-1236
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the effect of neurite out-growth inhibitor A/neurite outgrowth inhibitor receptor(Nogo-A/NgR)pathway on psychedelic-reduced pre-pulse inhibition in mice.Methods Mice were injec-ted intraperitoneally with psilocybin,DOI to establish an animal model of prepulse inhibition(PPI)reduc-tion.The effects of psilocybin and DOI on PPI in mice after lateral ventricular injection of Nogo-A inhibitor NEP1-40 30 min in advance were evaluated.Finally,Rtn4r knockout mice were constructed to further verify the conclusion.Results The injection of NEP1-40(1 g·L-1,5 μL/mice,i.c.v)30 min in advance had no effect on PPI of mice.Under the conditions of 70 dB and 75 dB prepulse stimulation,NEP1-40 significantly up-regulated the PPI reduction induced by psilocybin.At the same time,NEP1-40 significantly up-regulated the DOI induced PPI reduction in mice at 70 dB and 80 dB prepulse stimulation.Compared with the two solvent groups,the PPI of Rtn4r-/-mice was not differ-ent from that of wild-type mice.Compared with the mice in Rtn4r-/-solvent group,the PPI of mice in Rtn4r-/-administration group showed a decreasing trend,but had no significant difference.Under the con-dition of 70 dB prepulse stimulation,there was a signif-icant difference between the Rtn4r-/-administration group and wild-type mice.Conclusion Nogo-A/NgR pathway is involved in the destruction of sensorimotor gating in mice by the psychedelic psilocybin or DOI.
