Engineered MSCs-EV for repairing cartilage damage with a focus on delivery of curcumin
- VernacularTitle:工程化MSCs-EV修复软骨损伤聚焦:递送姜黄素
- Author:
Xiao-ming DU
1
;
Yu-lin MA
;
Xue-qing DUAN
;
Zhao-xi YANG
;
Xian-zhe ZHANG
;
Jin-ming ZHANG
;
Yi-mei HU
Author Information
- Publication Type:Journal Article
- Keywords: curcumin; mesenchymal stem cells; extracellular vesicles; cartilage; tissue engineering; osteoarthritis
- From: Chinese Pharmacological Bulletin 2025;41(7):1222-1226
- CountryChina
- Language:Chinese
- Abstract: Mesenchymal stem cells(MSCs)play a crucial role in tissue repair and regeneration,and the extracellular vesicle(EV)released by them holds great promise for applications in clinical biomarkers,vaccines,and drug delivery.However,MSCs-derived EV(MSCs-EV)face challenges such as low pro-duction yield,poor retention,and targeted delivery issues.There-fore,engineering MSCs-EV to enhance their performance and en-able visual research has become a hot topic.Curcumin(CUR),an active component in traditional chinese medicine,exhibits pharmacological effects but has limited bioavailability.Using MSCs-EV as a carrier for CUR delivery can address its solubility and bioavailability challenges.This article reviews the drug loading methods,engineering strategies of MSCs-EV,and their important applications in the delivery and treatment of CUR for cartilage injury diseases.It provides a basis for the clinical ap-plication of engineered MSCs-EV in CUR delivery for cartilage repair,offering potential solutions to the challenges in cartilage tissue repair.
