TAFRO syndrome:one case report and literature review
10.3969/j.issn.1672-8467.2025.02.020
- VernacularTitle:TAFRO综合征1例并文献复习
- Author:
Man-man LI
1
;
Yun-hua HOU
;
Chen-chen WANG
;
Ming DING
;
Xiao-xiao WANG
;
Zheng WEI
Author Information
1. 复旦大学附属闵行医院血液肿瘤科 上海 201199
- Publication Type:Journal Article
- Keywords:
TAFRO syndrome;
Castleman disease;
edema;
thrombocytopenia;
renal insufficiency
- From:
Fudan University Journal of Medical Sciences
2025;52(2):305-310
- CountryChina
- Language:Chinese
-
Abstract:
TAFRO syndrome is a systemic inflammatory disease with unknown etiology.It has low incidence rate and progresses rapidly,which poses a significant challenge for clinicians to make a timely diagnosis and provide reasonable treatment.This article retrospectively analyzed a 65-year-old male patient with iMCD-TAFRO admitted to Minhang Hospital,Fudan University,and visited the Department of Nephrology due to bilateral lower limb edema.The patient exhibited systemic edema,fever,and multiple enlarged lymph nodes.A comprehensive examination showed thrombocytopenia,renal dysfunction,elevated CRP levels,multiple serosal fluid accumulations,and bone marrow reticulin fibrosis.For further diagnosis and treatment,he visited the Hematology Clinic of Zhongshan Hospital,Fudan University.Based on the clinical manifestations,the diagnosis of TAFRO syndrome was considered.After further lymph node pathological consultation,the diagnosis was confirmed as idiopathic multicentric Castleman disease(iMCD)-TAFRO syndrome.Later,the patient was transferred to the hematology department of Minhang Hospital,Fudan University.After 15 days of treatment with methylprednisolone,cyclosporine A,rituximab,and thrombopoietin,there was no significant improvement in the condition.Due to personal reasons,the patient discontinued further treatment and passed away 2 weeks later.
