Mechanism of cofilin in regulating prostate cancer progression and potential therapeutic strategies
- VernacularTitle:丝切蛋白调控前列腺癌进展的作用机制及潜在的治疗策略
- Author:
Fang-zhi FU
1
;
Li-tong WU
1
;
En-min FENG
1
;
Xiang ZHAO
1
;
Neng WANG
1
;
Biao WANG
1
;
Qing ZHOU
1
Author Information
- Publication Type:Journal Article
- Keywords: cofilin; cleavage; actin-binding protein; cytoskele-ton; prostate cancer; phosphorylation
- From: Chinese Pharmacological Bulletin 2025;41(7):1206-1211
- CountryChina
- Language:Chinese
- Abstract: The molecular mechanisms underlying the develop-ment and metastasis of prostate cancer remain elusive.This comprehensive review delves into the intricate role of cofilin,an actin-binding protein,in the pathogenesis and progression of prostate cancer.Cofilin is a significant protein in cytoskeletal dynamics,and any dysregulation may result in the morphological changes in normal cells and the invasion and metastasis of tumor cells.Research has revealed that the activity of cofilin is regula-ted by various mechanisms,including phosphorylation/dephos-phorylation and interactions with other molecules.Moreover,this review discusses promising therapeutic interventions,such as co-filin inhibitors and gene therapy,which have demonstrated effica-cy in preclinical models.The challenge of clinically preventing the transition to castration-resistant prostate cancer and tumor metastasis is widely recognized,necessitating the development of precise drug treatments and biomarker identification.As a key regulatory protein,cofilin provides a more comprehensive refer-ence for the prevention and treatment of prostate diseases.
