Research progress on the mechanism of FATP2 in lipid nephrotoxicity
10.3969/j.issn.1672-8467.2025.02.017
- VernacularTitle:FATP2在脂质肾毒性中的机制研究进展
- Author:
Yan-qi LI
1
;
Jia-yan ZHONG
1
;
Hui-juan WU
1
Author Information
1. 复旦大学基础医学院病理学系 上海 200032
- Publication Type:Journal Article
- Keywords:
fatty acid transport protein 2(FATP2);
chronic kidney disease(CKD);
proximal renal tubule;
lipotoxicity;
free fat acid(FFA)
- From:
Fudan University Journal of Medical Sciences
2025;52(2):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal lipid metabolism and renal ectopic lipid accumulation have been associated with the occurrence and development of kidney diseases,particularly in diabetic nephropathy.However,the drugs commonly used in clinic to treat hypercholesterolemia,such as statins,ezetimibe and proprotein convertase subtilisin/Kexin type 9(PCSK9)inhibitors,can effectively reduce the blood lipid level,but fail to delay the progress of kidney disease.In recent years,an increasing number of research studies have focused on the impact of free fat acids(FFA)metabolism on kidney function.The profiles and metabolism of fatty acids are altered in chronic kidney disease(CKD),and deregulated fatty acid metabolism contributes to further kidney damage.Furthermore,the role of FFA transporter in the progression of kidney diseases is gradually recognized.Therefore,this review summarizes the recent preclinical researches of fatty acid transporter fatty acid transport protein 2(FATP2)expressed in proximal renal tubular epithelial cells.
