Disease burden and trends in enteric infections in China,1990-2021:a One Health perspective
10.3969/j.issn.1002-2694.2025.00.068
- VernacularTitle:基于One Health视角分析我国1990-2021年肠道传染病疾病负担变化情况
- Author:
Jing TAN
1
;
Fei WANG
;
Shi-pan CHEN
;
Xiao-chun LI
;
Hong-xin JU
;
Chun-xiao YANG
;
Wen-qiang YIN
;
Lan-hua LI
Author Information
1. 山东第二医科大学公共卫生学院,潍坊 261053;"健康山东"重大社会风险预测与治理协同创新中心,潍坊 261053;健康相关重大社会风险预警协同创新中心,上海 200032
- Publication Type:Journal Article
- Keywords:
enteric infectious diseases;
disease burden;
mortality rate;
One Health
- From:
Chinese Journal of Zoonoses
2025;41(5):472-479
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzed the burden and trends in enteric infections in China from 1990 to 2021 from a One Health perspec-tive.Data on mortality associated with enteric infections were extracted from the 2021 Global Burden of Disease(GBD)database.The analysis focused on assessing the mortality rates of enteric infectious diseases attributed to various etiologies and risk factors,along with the age and sex distribution,from 1990 to 2021.Average annual percentage change(AAPC)was used to assess the total changes in disease burden.The age-standardized mortality rate of intestinal infections in China decreased from 9.642/100 000 in 1990 to 0.439/100 000 in 2021,with an AAPC of-57.103%(95%CI:-57.118%to-57.088%).In 2021,Rotavirus,Norovirus,and Crypto-sporidium were the top three etiologies contributing to disease burden,with mortality rates of 1.020/100 000,0.040/100 000 and 0.079/100 000,respectively.A significant variation in etiology distribution was observed across age groups:Rotavirus,Shigella,and Crypto-sporidium dominated among children under 5 years of age,whereas Cryptosporidium,Norovirus,and Clostridioides difficile were more prevalent in older populations.Risk factor analysis indicated that unsafe water sources and poor sanitation accounted for 73.394%of all enteric disease-related deaths.In conclusion,the burden of enteric infections in China markedly declined from 1990 to 2021,and sig-nificant variations in the etiological spectrum and disease burden were observed across age groups.The persistent effects of unsafe wa-ter sources and poor sanitation underscore the need for targeted interventions to further decrease the burden of these diseases.Our find-ings highlight the success of public health interventions in decreasing the burden of enteric infections in China,while emphasizing the need for targeted measures to address disparities in high-risk populations and improve environmental sanitation.
