Association between malignant haematological diseases and frailty:a bidirectional Mendelian randomisation study
10.3969/j.issn.1671-8283.2025.02.003
- VernacularTitle:基于双向孟德尔随机化的恶性血液病与衰弱因果关系
- Author:
Mengying LI
1
;
Jianyao LI
;
Qingzhen FAN
;
Meixiang KE
;
Ruyi ZHOU
;
Hong HU
Author Information
1. 九江市第一人民医院九江市细胞治疗重点实验室 血液内科,江西 九江,332000
- Publication Type:Journal Article
- Keywords:
malignant haematological disease;
frailty;
frailty index;
Mendelian randomisation;
datasets in genome-wide association studies
- From:
Modern Clinical Nursing
2025;24(2):23-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse and explore whether there is a causal association without confounding factors between malignant haematological diseases and frailty based on a bidirectional Mendelian randomisation(MR)analysis,and to provide a theoretical basis for clinical management of the frailty associated with malignant haematological diseases.Methods In December 2023,the IEU OpenGWAS database(https://gwas.mrcieu.ac.uk/)was searched to acquire the datasets in genome-wide association studies(GWAS)derived from non-overlapping multi-ethnic populations based on Mendelian Randomisation(MR)analysis.The bidirectional causal association was verified utilising the two-sample MR approach.Single nucleotide polymorphisms(SNPs)of the frailty index(FI)(n=175,226),haematological malignancies(n=212,453),multiple myeloma/malignant plasmacytoma(n=218,792),and follicular lymphoma(n=181,278)were used as the study instruments.Results The analysis with the statistic inverse variance weighted method(IVW)showed that haematological malignancies(OR=1.00,95%CI:0.98-1.00,P=0.797),multiple myeloma/malignant plasma cell tumours(OR=1.00,95%CI 0.99～1.01,P=0.982),and follicular lymphoma(OR=1.00,95%CI:0.99～1.01,P=0.314)were not causally associated with genetically predicted FI.Similarly,FI was not significantly or causally correlated with haematological malignancies(OR=0.89,95%CI:0.25～3.12,P=0.861),multiple myeloma/malignant plasma cell tumours(OR=0.52,95%CI:0.00～3.13,P=0.473),and follicular lymphoma(OR=1.06,95%CI:0.00～5.19,P=0.944).Conclusion No causal relationship between the malignant haematological diseases and frailty was found in this study.It suggests that other factors might exist to cause the malignant haematological frailty.
