Research progress of microglia regulation of synaptic plasticity in depression
- VernacularTitle:小胶质细胞调节突触可塑性在抑郁症中的研究进展
- Author:
Hua-qing LAI
1
;
Ping-long FAN
;
Zhen-zhen WANG
;
Nai-hong CHEN
Author Information
- Publication Type:Journal Article
- Keywords: depression; microglia; synaptic plasticity; synaptic pruning; synaptic engulfment; synapse loss
- From: Chinese Pharmacological Bulletin 2025;41(7):1201-1205
- CountryChina
- Language:Chinese
- Abstract: Depression,characterized by high incidence,high re-lapse rate and high suicide rate,is an affective disorder mainly characterized by low mood and often accompanied by suicidal tendency,which seriously endangers human health.In recent years,more and more evidence suggests that microglia regulate synaptic plasticity and play an important role in depression.Here we outline the recent research progress of microglia regula-ting synaptic plasticity to exert antidepressant effects,focusing on three main types of molecular signals regulating synaptic pruning in microglia,including"Find Me"signaling,"Eat Me"signaling and"Don't Eat Me"signaling.By reviewing recent studies on how microglia regulate synaptic plasticity in depression,hopeful-ly,the understanding of microglia-mediated synaptic plasticity can be strengthened,which can help to provide new strategies for the treatment of depression by targeting microglia or microglia-associated signaling pathways.
