Research progress in probiotics against Candida albicans infection
10.3969/j.issn.1002-2694.2025.00.085
- VernacularTitle:益生菌抗白色念珠菌感染的研究进展
- Author:
Da-lang YU
1
;
Sheng-wang YAN
Author Information
1. 南昌大学抚州医学院基础医学院,抚州 344000
- Publication Type:Journal Article
- Keywords:
probiotics;
Candida albicans;
infection;
mechanism
- From:
Chinese Journal of Zoonoses
2025;41(5):553-558
- CountryChina
- Language:Chinese
-
Abstract:
The infection incidence rate of Candida albicans,an opportunistic pathogenic fungus,has increased each year.Currently,the increased number of patients with immunodeficiency,the limited number of antifungal drugs,and drug resistance are the main reasons for the high incidence and high mortality of C.albicans related diseases.Therefore alternative therapies for combating C.albicans infections are urgently needed.Many recent studies have suggested that probiotics might inhibit C.albicans infection both directly,through inhibiting adhesion,growth,and biofilm formation,and indirectly,through regulating the host immune response,without leading to drug resistance.Because of the multiple pathways involved in these effects,the mechanism of probiotics in combating C.albicans infection has not been fully elucidated,and systematic evaluations of this mechanism are lacking.This article provides an in-depth analysis of the mechanism of probiotics in combating C.albicans infection described in recent years,to contribute to the development of new methods to resist C.albicans infection and,more importantly,the clinical development of new therapies for the treatment of drug-resistant fungal infections.
