Research progress of antimicrobial peptide LL-37 and autoimmune diseases
10.3969/j.issn.1000-484X.2025.03.043
- VernacularTitle:抗菌肽LL-37与自身免疫性疾病的研究进展
- Author:
Mengjing WU
1
;
Daqi ZHANG
1
;
Qifu LI
1
;
Xiaoping LIAO
1
Author Information
1. 海南医科大学第一附属医院神经内科,海口 570102
- Publication Type:Journal Article
- Keywords:
LL-37;
Antimicrobial peptide;
Autoimmune disease;
Immunoregulation
- From:
Chinese Journal of Immunology
2025;41(3):756-759
- CountryChina
- Language:Chinese
-
Abstract:
LL-37 is a widely-distributed human antimicrobial peptide with antimicrobial activity.In recent years,it has been found that LL-37 not only has antibacterial effect,but also can exert comprehensive immune regulatory function on different immune cells in different microenvironments,and then play a pro-inflammatory or anti-inflammatory role in a series of autoimmune diseases.This article focuses on immunomodulatory effect of LL-37 and its possible role in autoimmune diseases.
