Research overview and progress of single-cell sequencing analysis of BCR CDR3 receptor repertoire
10.3969/j.issn.1000-484X.2025.03.041
- VernacularTitle:单细胞测序分析BCR CDR3受体库的研究概况和进展
- Author:
Lanwei ZHU
1
;
Jun LI
1
;
Long MA
1
;
Xinsheng YAO
1
Author Information
1. 遵义医科大学基础医学院免疫学教研室,遵义 563000
- Publication Type:Journal Article
- Keywords:
B cell receptor;
CDR3 receptor library;
Single-cell sequencing
- From:
Chinese Journal of Immunology
2025;41(3):743-750
- CountryChina
- Language:Chinese
-
Abstract:
B cell receptor(BCR)is the main molecular basis for B cell specific recognition and binding of antigen,and its complementarity determining region(CDR3)presents high diversity and specificity.Using single-cell immune repertoire sequencing technology can accurately analyze the composition and characteristics of each B cell BCR CDR3 sequence,and can better understand the process and mechanism of B cell differentiation,development,and response.Single-cell immune repertoire sequencing technology provides new ideas and theoretical basis for the pathogenesis,monitoring,diagnosis and treatment of B-cell immune-related diseases.This paper mainly compares and analyzes the commonly used detection methods and detection platforms of B-cell BCR CDR3 receptor library,and focuses on the application,research status and progress of single-cell sequencing technology in B-cell BCR CDR3 recep-tor library.
