Progress of m6A modification involved in regulation of innate immunity
10.3969/j.issn.1000-484X.2025.03.037
- VernacularTitle:m6A修饰参与调控天然免疫的研究进展
- Author:
Chenzhen XU
1
;
Ning LI
1
;
Wenjie WANG
1
;
Qing GENG
1
Author Information
1. 武汉大学人民医院胸外科,武汉 430060
- Publication Type:Journal Article
- Keywords:
N6-methyladenosine;
Innate immunity;
Virus;
Macrophages
- From:
Chinese Journal of Immunology
2025;41(3):721-726
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine(m6A)modification is considered to be the most common eukaryotic RNA modification.Under regulation of writers,erasers and readers,m6A mediates RNA transcription,nuclear export,splicing,translation and other processes.Innate immunity is body's first line of defense against pathogen invasion,and under stimulation of pathogens and foreign bodies,it rapidly produces non-specific protective response.Recent studies have found that m6A modification plays an important role in process of innate immunity,participating in regulation of innate immunity by targeting innate immune cells,affecting immune recognition,and regulating antiviral responses.This article reviews molecular mechanism of m6A modification and its progress in innate immunity,providing new ideas for treatment strategies of related diseases based on m6A modification.
