Research progress of S100a8 and S100a9 in pathogenesis of bronchial asthma

VernacularTitle:S100a8、S100a9在支气管哮喘发生机制中的研究进展
Author: Xiaohui YUAN ¹ ; Liyan CHEN
Author Information

1. 广州医科大学附属第一医院广州呼吸健康研究院,呼吸疾病国家重点实验室,国家呼吸疾病临床医学研究中心,广州 510120
Publication Type:Journal Article
Keywords: S100a8; S100a9; Asthma; AHR
From: Chinese Journal of Immunology 2025;41(3):704-708
CountryChina
Language:Chinese
Abstract: S100a8 and S100a9 protein are important members of the S100 protein family.It can induce inflammation by acti-vating intracellular signal cascade,and its strong calcium binding ability makes it play an important role in regulating cell contraction.It has been reported that S100a8 and S100a9 could not only regulate asthmatic airway inflammation,but also have a protective effect on asthmatic airway hyperresponsiveness.This article intends to review the role of S100a8 and S100a9 proteins in airway inflammation and airway hyperresponsiveness in asthma,so as to provide new ideas for the research and prevention of asthma.