Effects of early endoscopic enteral nutrition support on immunoglobulins and T lymphocyte subsets in patients with severe intracerebral hemorrhage
10.3969/j.issn.1000-484X.2025.03.030
- VernacularTitle:早期内镜肠内营养支持对重症脑出血患者免疫球蛋白及T淋巴细胞亚群的影响
- Author:
Jingxia CHEN
1
;
Xiaobin LIAO
1
;
Chengxiang KANG
1
Author Information
1. 郴州市第一人民医院神经外科,郴州 423400
- Publication Type:Journal Article
- Keywords:
Severe intracerebral hemorrhage;
Enteral nutrition support;
Endoscopy;
Immunoglobulin;
T lymphocyte subset
- From:
Chinese Journal of Immunology
2025;41(3):686-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore effects of early endoscopic enteral nutrition support on immunoglobulin and T lymphocyte subsets in patients with severe intracerebral hemorrhage.Methods:A total of 120 patients with severe intracerebral hemorrhage admit-ted to The First People's Hospital of Chenzhou were enrolled between August 2019 and June 2022,who were divided into gastric tube group and intestinal tube group according to random number table method,with 60 cases in each group.Gastric tube group was given nasogastric tube 12～24 h after admission,while intestinal tube group was given gastroscope-assisted nasojejunal tube for early nutri-tion support.NIHSS and GCS scores,nutritional indexes[albumin(Alb),prealbumin(PAB),hemoglobin(Hb)],IgG,IgA,IgM and T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)levels on the following day and 14 d after admission,and complications were compared between two groups.Results:At 14 d after admission,NIHSS score in intestinal tube group were significantly lower than gastric tube group,while GCS score,peripheral blood Alb,PAB,Hb,IgG,IgA,IgM,CD3+T,CD4+T and CD4+T/CD8+T levels were signifi-cantly higher than gastric tube group(P<0.05).After treatment,incidences of gastrointestinal bleeding,reflux esophagitis,gastric retention and vomiting in intestinal tube group were lower than gastric tube group(P<0.05).Conclusion:Early endoscopic enteral nutrition support can effectively improve nutritional status and enhance immune function in patients with severe intracerebral hemorrhage,which is beneficial to improve prognosis.
