Analysis of clinical characteristics and prognostic factors of 51 patients with multiple sclerosis in Suzhou area
10.3969/j.issn.1000-484X.2025.03.029
- VernacularTitle:51例苏州地区多发性硬化患者的临床特征及预后影响因素分析
- Author:
Benyu QIAO
1
;
Xiaoke WU
;
Wenli SONG
;
Keru LI
;
Houde LI
;
Yu JIANG
;
Jinru ZHANG
;
Xiaodong XU
;
Dongqin CHEN
;
Yongjun CAO
;
Yanlin ZHANG
Author Information
1. 苏州大学附属第二医院神经内科,苏州 215000;连云港市中医院神经内科,连云港 222004
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Prognosis;
Late onset;
Clinical characteristics
- From:
Chinese Journal of Immunology
2025;41(3):680-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore clinical characteristics of multiple sclerosis(MS)patients in Suzhou,and to analyze main factors affecting their prognosis.Methods:General data,clinical symptoms,cerebrospinal fluid and imaging examinations of 51 MS patients admitted to Department of Neurology of the Second Hospital of Soochow University from July 31,2009 to July 31,2021 were retrospectively analyzed,and main factors affecting their prognosis were discussed.Results:Average age of onset of 51 MS patients was(43.3±15.6)years old,female accounted for 56.9%,male/female=1/1.3.Adult onset MS(AOMS)accounted for 62.8%,male/female=1/1.7;late onset MS(LOMS)accounted for 37.2%,male/female=1/0.9.Relapsing remitting MS(RRMS)accounted for 76.5%,and chronic onset accounted for 60.8%.Average annual recurrence rate was 8.8%.The first symptoms were numbness and weakness of limbs.Dizziness and numbness were more common in patients without recurrence after diagnosis of MS,and limb weak-ness and numbness were more common in patients with recurrence.Among lesions of MRI,62.7%(32/51)of periventricular involve-ment,52.9%(27/51)of spinal cord involvement,51.0%(26/51)of infratentorial involvement.Proportion of subtentorial and spinal cord(cervical,thoracic)involved were significantly higher in patients with recurrent MS than without recurrence.Values of albumin,IgG,IgA and IgM in cerebrospinal fluid increased with increase of recurrence times.EDSS score of male was higher than female,and LOMS score was higher than AOMS.MS patients without relapse had a low EDSS score,and median EDSS score at current follow-up was 0(0,1.00)score.MS score with relapse was relatively high,and median EDSS score at current follow-up was 2.75(0.25,7.25)score.Conclusion:MS patients with chronic onset are more common,with a high proportion of LOMS,and proportion of males increases with increasing age of onset.High EDSS score at first onset,cervical,thoracic and subtentorial lesions,increased values of cerebrospinal fluid albumin,IgG,IgA,IgM,age at first onset(50+years old),male associate with poor MS prognosis.
