Subcutaneous hematoma complicated with rhabdomyolysis caused by sudden overdose of warfarin:a case report
10.12173/j.issn.1005-0698.202502117
- VernacularTitle:过量服用华法林致皮下血肿合并横纹肌溶解1例
- Author:
Yinping ZHAO
1
;
Xiuping ZHAO
;
Xialing QIN
;
Haihua HE
;
Tao DAI
Author Information
1. 南方医科大学南方医院增城院区药学部(广州 511300)
- Publication Type:Journal Article
- Keywords:
Warfarin;
Subcutaneous hematoma;
Rhabdomyolysis;
Medication errors
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(6):720-724
- CountryChina
- Language:Chinese
-
Abstract:
This case involves a 53-year-old female patient who underwent mechanical mitral valve replacement and has been on long-term warfarin anticoagulant therapy,subsequently developed diffuse ecchymoses of the limbs and progressive both lower extremities swelling after she self-adjusted her warfarin dosage from 3 mg to 6 mg daily over 5 consecutive days.After admission,the patient's international normalized ratio was 12.71,and creatine kinase level was 1,989.47 U·L-1,which led to the diagnosis of coagulopathy and rhabdomyolysis due to warfarin overdose.Following discontinuation of warfarin and initiation of fluid resuscitation therapy,the patient's creatine kinase levels returned to normal after 6 d.Thiscase underscores the necessity of refining long-term warfarin management strategies and enhancing patient education to improve medication adherence and ensure both the efficacy and safety of anticoagulation therapy.
