Research progress on non-coding RNAs in the regulation of ferroptosis mediated sorafenib resistance in hepatocellular car-cinoma
10.11904/j.issn.1002-3070.2025.03.012
- VernacularTitle:非编码RNA调控铁死亡介导肝细胞癌索拉非尼耐药的研究进展
- Author:
Lei ZHU
1
;
Dandan HAO
Author Information
1. 赤峰学院附属医院检验科(赤峰 024005)
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Non-coding RNA;
Ferroptosis;
Sorafenib;
Biomarkers
- From:
Practical Oncology Journal
2025;(3):256-261
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a non-apoptotic programmed cell death driven by iron ion-mediated lipid peroxidation,which is closely related to the occurrence and development of various tumors.In recent years,many studies have shown that non-coding RNA(ncRNA)can affect tumor drug resistance by regulating the ferroptosis pathway.This article summarizes the molecular mechanisms of ncRNAs regulating sorafenib resistance in hepatocellular carcinoma(HCC)through ferroptosis,with a focus on the regulatory roles of different ncRNA subtypes such as microRNA(miRNA),long noncoding RNA(lncRNA),and circular RNA(circRNA).The article not only contributes to a deeper analysis of the key molecular mechanisms by which ncRNA mediate sorafenib resistance in HCC through ferroptosis pathways,but also provides a theoretical basis for exploring novel diagnostic biomarkers and therapeutic targets for HCC in the future.
