Pharmaceutical practice in the treatment of one case of ventilator-associated pneumonia caused by extensively drug-resistant Klebsiella pneumoniae
10.12173/j.issn.1005-0698.202502037
- VernacularTitle:1例广泛耐药肺炎克雷伯菌所致呼吸机相关性肺炎治疗的药学实践
- Author:
Minglu YUAN
1
;
Wei ZENG
;
Genzhu WANG
;
Xiaoying WANG
;
Zhongdong LI
Author Information
1. 国家电网公司北京电力医院/首都医科大学电力教学医院药剂科(北京 100073)
- Publication Type:Journal Article
- Keywords:
Extensively drug resistant Klebsiella pneumoniae;
Ventilator-associated pneumonia;
Anti-infective treatment;
Ceftazidime avibactam;
Colistin sulfate;
Pharmaceutical care
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(6):708-714
- CountryChina
- Language:Chinese
-
Abstract:
This article reports a postcraniotomy patient with renal insufficiency and electrolyte imbalance who developed ventilator-associated pneumonia caused by extensively drug-resistant Klebsiella pneumoniae.According to the patient's pathophysiological characteristics,bacterial epidemiological characteristics,and bacterial culture results,combined with the latest guidelines and the pharmacokinetic/pharmacodynamic characteristics of antibiotics,a full-dose ceftazidime/avibactam regimen was initially suggested by the clinical pharmacist,and which was adopted by doctor.When the effect of ceftazidime/avibactam was poor and no guideline-recommended alternatives were available,the clinical pharmacist,in conjunction with clinical experience,proposed a combination therapy of colistin sulfate and tigecycline,with the implementation of adverse reaction monitoring and mucin sulfate blood concentration monitoring.Finally,the pneumonia was effectively controlled,the inflammatory indicators such as temperature and the white blood cell count returned to normal,no adverse drug reactions occurred,and the patient was successfully transferred to the rehabilitation institution.Clinical pharmacists stay updated on the latest medication knowledge both domestically and internationally,recommend advanced drug treatment protocols for clinical practice,assist in managing severe infections,and play an important role in the clinical team.
